Treatment of Life threatening Lithium Toxicity With Continuous Arterio venous Hemodiafiltration

American Journal of Nephrology

Case Report

	Treatment of Life-Threatening Lithium Toxicity with High-Volume Continuous Venovenous Hemofiltration van Bommel E.F.H.a · Kalmeijer M.D.b · Ponssen H.H.a aDepartments of Medicine and bClinical Pharmacy, Albert Schweitzer Hospital, Location Amstelwijck, Dordrecht, The Netherlands Related Articles for ""

Am J Nephrol 2000;20:408–411

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Article / Publication Details

First-Page Preview

Published online: November 15, 2000
Issue release date: September – October

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

There is still debate as to the preferred extracorporeal treatment modality for severe lithium intoxication. Because lithium is readily diffusable, intermittent hemodialysis is usually performed. However, this bares the risk of a post-dialysis rebound concentration and, in the case of severe lithium poisoning collapse, aggravation of hemodynamic instability. Because of the relatively slow but continuous solute removal, continuous renal replacement therapy (CRRT) may be advantageous. We report the first case in the literature of severe lithium intoxication treated effectively with high-volume continuous venovenous hemofiltration (HV-CVVH). Results compared favorably to other forms of CRRT in terms of lithium clearance. Ease of implementation, the excellent tolerability and the superior lithium clearance without rebound phenomenon may make HV-CVVH the preferred treatment modality for severe lithium poisoning.

© 2000 S. Karger AG, Basel

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References

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3. Bellomo R, Kearly Y, Parkin G, Love J, Boyce N: Treatment of life-threatening lithium toxicity with continuous arteriovenous hemodiafiltration. Crit Care Med 1991;19:836–837.
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7. Van Bommel EFH, Ponssen HH: Intermittent versus continuous treatment for acute renal failure: Where do we stand? Am J Kidney Dis 1997;30(suppl 4):72–79.
8. Bonnardeaux A, Pichette V, Quimet D, et al: Solute clearances with high dialysate flow rates and glucose absorption from the dialysate in continuous arteriovenous heomdialysis. Am J Kidney Dis 1992;19:31–38.
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Article / Publication Details

First-Page Preview

Published online: November 15, 2000
Issue release date: September – October

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

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